解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Proteomic analyses of the nucleolus have revealed almost 700 functionally diverse proteins implicated in ribosome biogenesis, nucleolar assembly, and regulation of vital cellular processes. However, this nucleolar inventory has not unveiled a specific consensus motif necessary for nucleolar binding. The ribosomal prot...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msn002
更新日期:2008-03-01 00:00:00
abstract::Proteins present in the seminal fluid of Drosophila melanogaster (accessory gland proteins Acps) contribute to female postmating behavioral changes, sperm storage, sperm competition, and immunity. Consequently, male-female coevolution and host-pathogen interactions are thought to underlie the rapid, adaptive evolution...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm270
更新日期:2008-03-01 00:00:00
abstract::We have investigated intron evolution in the compact genomes of 2 closely related species of pufferfishes, Fugu rubripes and Tetraodon nigroviridis, that diverged about 32 million years ago (MYA). Analysis of 148,028 aligned intron positions in 13,547 gene pairs using human as an outgroup identified 57 and 24 intron l...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm278
更新日期:2008-03-01 00:00:00
abstract::Cells react to oxidative stress conditions by launching a defense response through the induction of nuclear gene expression. The advent of microarray technologies allowed monitoring of oxidative stress-dependent changes of transcript levels at a comprehensive and genome-wide scale, resulting in a series of inventories...
journal_title:Molecular biology and evolution
pub_type: 杂志文章,meta分析
doi:10.1093/molbev/msm276
更新日期:2008-03-01 00:00:00
abstract::Alternative splicing (AS) contributes to increased transcriptome and proteome diversity in various eukaryotic lineages. Previous studies showed low levels of conservation of alternatively spliced (cassette) exons within mammals and within dipterans. We report a strikingly different pattern in Caenorhabditis nematodes-...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm262
更新日期:2008-02-01 00:00:00
abstract::Identifying mechanisms that underlie variation in adult survivorship provide insight into the evolution of life history strategies and phenotypic variation in longevity. There is accumulating evidence that shortening telomeres, the protective caps at the ends of chromosomes, play an important role in individual variat...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm244
更新日期:2008-01-01 00:00:00
abstract::R2 non-long terminal repeat retrotransposable elements insert specifically into the 28S rRNA genes of a wide range of animals. These elements maintain long-term stable relationships with the host genome. By scoring the variation present at the 5' ends of individual R2 copies, lines of Drosophila simulans have been ide...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm250
更新日期:2008-01-01 00:00:00
abstract::Examination of the genomic sequence of the telomere region makes it possible to understand the evolution of the structure of chromosomal ends. We compared the genomic sequences of 14 chromosomal ends of rice, Oryza sativa, L., on the basis of the variation in TTTAGGG repeats. In the proximal telomere repeats, nucleoti...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm227
更新日期:2008-01-01 00:00:00
abstract::The level of DNA polymorphism in the ancestral species at the time of speciation can be estimated using DNA sequences from many loci sampled from 2 or more extant species. The comparison between ancestral and extant polymorphism can be informative about the population genetics of speciation. In this study, we collecte...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm209
更新日期:2007-12-01 00:00:00
abstract::That natural selection affects molecular evolution at synonymous sites in protein-coding sequences is well established and is thought to predominantly reflect selection for translational efficiency/accuracy mediated through codon bias. However, a recently developed maximum likelihood framework, when applied to 18 codi...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm196
更新日期:2007-12-01 00:00:00
abstract::Recently, many cases of rapid adaptive evolution, which is characterized by the higher substitution rates of nonsynonymous substitutions to synonymous ones, have been identified in the various genes of venomous and biodefense proteins, including the conger eel galectins, congerins I and II (ConI and ConII). To underst...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm185
更新日期:2007-11-01 00:00:00
abstract::Spatial distribution and clustering of repetitive elements are extensively studied during the last years, as well as their colocalization with other genomic components. Here we investigate the large-scale features of Alu and LINE1 spatial arrangement in the human genome by studying the size distribution of interrepeat...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm181
更新日期:2007-11-01 00:00:00
abstract::Many intron positions are conserved in varying subsets of eukaryotic genomes and, consequently, comprise a potentially informative class of phylogenetic characters. Roy and Gilbert developed a method of phylogenetic reconstruction using the patterns of intron presence-absence in eukaryotic genes and, applying this met...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm207
更新日期:2007-11-01 00:00:00
abstract::There are many examples of groups (such as birds, bees, mammals, multicellular animals, and flowering plants) that have undergone a rapid radiation. In such cases, where there is a combination of short internal and long external branches, correctly estimating and rooting phylogenetic trees is known to be a difficult p...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm178
更新日期:2007-11-01 00:00:00
abstract::Animal microRNAs (miRNAs) are short RNAs that function as posttranscriptional regulators of gene expression by binding to the target mRNAs. Noting that some miRNAs are highly conserved in evolution, we explored the possibility of evolutionary conservation of their targets. We identified human orthologues of experiment...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm195
更新日期:2007-11-01 00:00:00
abstract::Silks are strong protein fibers produced by a broad array of spiders and insects. The vast majority of known silks are large, repetitive proteins assembled into extended beta-sheet structures. Honeybees, however, have found a radically different evolutionary solution to the need for a building material. The 4 fibrous ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm171
更新日期:2007-11-01 00:00:00
abstract::It is well known that molecular data "saturates" with increasing sequence divergence (thereby losing phylogenetic information) and that in addition the accumulation of misleading information due to chance similarities or to systematic bias may accompany saturation as well. Exploratory data analysis methods that can qu...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm139
更新日期:2007-09-01 00:00:00
abstract::Here we use phylogenomics with expressed sequence tag (EST) data from the ecologically important coccolithophore-forming alga Emiliania huxleyi and the plastid-lacking cryptophyte Goniomonas cf. pacifica to establish their phylogenetic positions in the eukaryotic tree. Haptophytes and cryptophytes are members of the p...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm089
更新日期:2007-08-01 00:00:00
abstract::The adaptive significance of enzyme variation has been of central interest in population genetics. Yet, how natural selection operates on enzymes in the larger context of biochemical pathways has not been broadly explored. A basic expectation is that natural selection on metabolic phenotypes will target enzymes that c...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm057
更新日期:2007-06-01 00:00:00
abstract::The question of multiple sequence alignment quality has received much attention from developers of alignment methods. Less forthcoming, however, are practical measures for addressing alignment quality issues in real life settings. Here, we present a simple methodology to help identify and quantify the uncertainties in...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm060
更新日期:2007-06-01 00:00:00
abstract::Phylogenetic relationships among the 5 groups of extant seed plants are presently unsettled. To reexamine this long-standing debate, we determine the complete chloroplast genome (cpDNA) of Cycas taitungensis and 56 protein-coding genes encoded in the cpDNA of Gnetum parvifolium. The cpDNA of Cycas is a circular molecu...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm059
更新日期:2007-06-01 00:00:00
abstract::The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes posttranslationally. The small translocase of the inner mitochondrial membranes (TIMs) are a group of approximately 10 kDa proteins that function as chaperones to ferry the imported protein...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm031
更新日期:2007-05-01 00:00:00
abstract::The complete nucleotide sequence of the mt (mitochondrial) and cp (chloroplast) genomes of the unicellular green alga Ostreococcus tauri has been determined. The mt genome assembles as a circle of 44,237 bp and contains 65 genes. With an overall average length of only 42 bp for the intergenic regions, this is the most...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm012
更新日期:2007-04-01 00:00:00
abstract::Nonsense-mediated decay (NMD) pathways for detection and degradation of transcripts containing premature termination (stop) codons (PTCs) are ubiquitous among the eukaryotes. NMD uses the presence of a second signal downstream of a termination codon to distinguish a PTC from a true stop codon. In mammals and perhaps o...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msm010
更新日期:2007-04-01 00:00:00
abstract::Understanding how pathogens acquire resistance to drugs is important for the design of treatment strategies, particularly for rapidly evolving viruses such as HIV-1. Drug treatment can exert strong selective pressures and sites within targeted genes that confer resistance frequently evolve far more rapidly than the ne...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm021
更新日期:2007-04-01 00:00:00
abstract::Varying degrees of reduction of genetic diversity in crops relative to their wild progenitors occurred during the process of domestication. Such information, however, has not been available for the Asian cultivated rice (Oryza sativa) despite its importance as a staple food and a model organism. To reveal levels and p...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm005
更新日期:2007-03-01 00:00:00
abstract::We present QNet, a method for constructing split networks from weighted quartet trees. QNet can be viewed as a quartet analogue of the distance-based Neighbor-Net (NNet) method for network construction. Just as NNet, QNet works by agglomeratively computing a collection of circular weighted splits of the taxa set which...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl180
更新日期:2007-02-01 00:00:00
abstract::Insertion and deletion (indel)-based analyses have great potential for rooting the tree of life, but their use has been limited because they require ubiquitous sequences that have not been horizontally/laterally transferred. Very few such sequences exist. Here we describe and demonstrate a new algorithm that can use n...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl140
更新日期:2007-01-01 00:00:00
abstract::An attempt to use phylogenetic invariants for tree reconstruction was made at the end of the 80s and the beginning of the 90s by several researchers (the initial idea due to Lake [1987] and Cavender and Felsenstein [1987]). However, the efficiency of methods based on invariants is still in doubt (Huelsenbeck 1995; Jin...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl153
更新日期:2007-01-01 00:00:00
abstract::Influenza A viruses from wild aquatic birds, their natural reservoir species, are thought to have reached a form of stasis, characterized by low rates of evolutionary change. We tested this hypothesis by estimating rates of nucleotide substitution in a diverse array of avian influenza viruses (AIV) and allowing for ra...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl102
更新日期:2006-12-01 00:00:00
abstract::It has recently been observed by Ho et al. (Ho SYW, Phillips MJ, Cooper A, Drummond AJ. 2005. Time dependency of molecular rate estimates and systematic overestimation of recent divergence times. Mol Biol Evol. 22(7):1561-1568) that apparent rates of molecular evolution increase when measured over short timespans. I i...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl107
更新日期:2006-12-01 00:00:00
abstract::Identification of recently gained spliceosomal introns would provide crucial evidence in the continuing debate concerning the age and evolutionary significance of introns. A previously published genomic analysis reported to have identified 122 introns that had been gained since the divergence of the nematodes Caenorha...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl098
更新日期:2006-12-01 00:00:00
abstract::In Arabidopsis, stem cell homeostasis in the shoot apical meristem (SAM) is controlled by a feedback loop between WUS and CLV functions. We have identified WUS orthologues in maize and rice by a detailed phylogenetic analysis of the WOX gene family and subsequent cloning. A single WUS orthologue is present in the rice...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl125
更新日期:2006-12-01 00:00:00
abstract::The phylogenetic relationships of the biflagellate protist group Apusomonadidae have been unclear despite the availability of some molecular data. We analyzed sequences from 6 nuclear encoded genes-small-subunit rRNA, large-subunit rRNA, alpha-tubulin, beta-tubulin, actin, and heat shock protein 90-to infer the phylog...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl120
更新日期:2006-12-01 00:00:00
abstract::Successful fertilization in free-spawning marine organisms depends on the interactions between genes expressed on the surfaces of eggs and sperm. Positive selection frequently characterizes the molecular evolution of such genes, raising the possibility that some common deterministic process drives the evolution of gam...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl062
更新日期:2006-10-01 00:00:00
abstract::A recent investigation found evidence that the transition of Arabidopsis thaliana from ancestral self-incompatibility (SI) to full self-compatibility occurred very recently and suggested that this occurred through a selective fixation of a nonfunctional allele (PsiSCR1) at the SCR gene, which determines pollen specifi...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl042
更新日期:2006-09-01 00:00:00
abstract::Selection on phenotypes may cause genetic change. To understand the relationship between phenotype and gene expression from an evolutionary viewpoint, it is important to study the concordance between gene expression and profiles of phenotypes. In this study, we use a novel method of clustering to identify genes whose ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl019
更新日期:2006-08-01 00:00:00
abstract::We recently introduced a novel method for estimating selection pressures on proteins, termed "volatility," which requires only a single genome sequence. Some criticisms that have been levied against this approach are valid, but many others are based on misconceptions of volatility, or they apply equally to comparative...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msl021
更新日期:2006-08-01 00:00:00
abstract::The authors of a recent manuscript in "Nature" claim to have discovered "universal trends" of amino acid gain and loss in protein evolution. Here, we show that this universal trend can be simply explained by a bias that is unavoidable with the 3-taxon trees used in the original analysis. We demonstrate that a rigorous...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msl010
更新日期:2006-07-01 00:00:00
abstract::Mitochondrial transcription factor B (mtTFB), an essential component in regulating the expression of mitochondrial DNA-encoded genes in both yeast and humans, is a dimethyladenosine methyltransferase (DMT) that has acquired a secondary role in mitochondrial transcription. So far, mtTFB has only been well studied in Op...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msk001
更新日期:2006-06-01 00:00:00